肿瘤人源化靶点模型

小鼠因其与人类基因组99%的相似性以及生理、生化指标的相似,已经成为使用最广泛的临床前药物评价模型及疾病模型之一。虽然二者基因组有着极其高度的相似性,但是某些蛋白的功能结构域,例如受体与供体结合位点,在小鼠和人之间仍然可能存在差异。另外,研究发现,某些人源基因在小鼠中也缺少同源基因。因此,在小鼠模型上对靶向这类人源蛋白的大分子药物进行临床前评价时,需要构建该类蛋白(基因)人源化的小鼠模型。集萃药康拥有一系列自主产权的肿瘤靶点人源化小鼠模型,这些人源化小鼠是筛选和评价抗肿瘤药物药效及安全性的理想模型。

品系编号 靶点 品系简称

T009882

VTCN1

BALB/c-hVTCN1

T009880

VTCN1

B6-hVTCN1

T059647

VSIG4

BALB/c-hVSIG4

T014757

VISTA

BALB/c-hVISTA

T054369

VEGFR1(FLT1)

B6-hVEGFR1(FLT1)

T054677

VEGFD

B6-hVEGFD

T055634

VEGFC

BALB/c-hVEGFC

T055633

VEGFB

BALB/c-hVEGFB

T054634

VEGFB

B6-hVEGFB

T059100

VEGFA/VEGFR2

BALB/c-hVEGFA/hVEGFR2

T017804

VEGFA

NCG-hVEGFA

T017803

VEGFA

BALB/c-hVEGFA

T056432

TROP2

BALB/c-hTROP2

T058949

TREM2

BALB/c-hTREM2

T056008

TREM2

B6-hTREM2

T064513

TREM1

BALB/c-hTREM1

T055353

TPOR

BALB/c-hTPOR

T058456

TNFR2

BALB/c-hTNFR2

T037079

TNFR2

BALB/c-hPD1/hTNFR2

T055369

TNFR2

BALB/c-hPD1/hPDL1/hTNFR2

T054585

TLR9

BALB/c-hTLR9

T054584

TLR9

B6-hTLR9

T054553

TLR7

BALB/c-hTLR7

T054552

TLR7

B6-hTLR7

T056526

TLR2

BALB/c-hTLR2

T003894

TIM3

BALB/c-hTIM3

T004795

TIM3

BALB/c-hPD1/hTIM3

T007059

TIM3

BALB/c-hPD1/hPDL1/hTIM3

T009737

TIM3

B6-hPD1/hTIM3

T058266

TIGIT/PVRIG

BALB/c-hTIGIT/hPVRIG

T059704

TIGIT/PVRIG

BALB/c-hPD1/hPDL1/hTIGIT/hPVRIG

T056729

TIGIT/OX40

BALB/c-hTIGIT/hOX40

T055241

TIGIT/CTLA4

BALB/c-hTIGIT/hCTLA4

T054842

TIGIT/CD96

BALB/c-hPD1/hPDL1/hTIGIT/hCD96

T054841

TIGIT/CD226

BALB/c-hPD1/hPDL1/hTIGIT/hCD226

T059259

TIGIT/CD155

BALB/c-hTIGIT/hCD155-full

T059258

TIGIT/CD155

BALB/c-hTIGIT/hCD155

T003365

TIGIT

BALB/c-hTIGIT

T004023

TIGIT

BALB/c-hPD1/hTIGIT

T051156

TIGIT

BALB/c-hPD1/hPDL1/hTIGIT/hCTLA4

T037004

TIGIT

BALB/c-hPD1/hPDL1/hTIGIT

T058886

TIGIT

BALB/c-hFcgRs-Tg/hTIGIT/mFcgRs-KO

T003366

TIGIT

B6-hTIGIT

T004024

TIGIT

B6-hPD1/hTIGIT

T006873

TIGIT

B6-hPD1/hPDL1/hTIGIT

T064267

TGFR2

B6-hTGFR2

T064266

TGFR1

B6-hTGFR1

T054838

TGFB2

BALB/c-hTGFB2

T054837

TGFB1

BALB/c-hTGFB1

T055118

TFRC(TfR1)

BALB/c-hTFRC(hTfR1)

T054281

TDO2

B6-hTDO2

T054362

TACSTD2(TROP2)

NCG-hTACSTD2(TROP2)

T056080

SSTR2

BALB/c-hSSTR2

T005314

SIRPα

BALB/c-hPD1/hSIRPα

T050194

SIRPα

BALB/c-hPD1/hPDL1/hSIRPα

T004615

SIRPα

B6-hSIRPα

T006929

SIRPα

B6-hPD1/hSIRPα

T036819

SIRPA

B6-hPD1/hPDL1/hSIRPA

T037008

SIGLEC9

BALB/c-hSIGLEC9

T037010

SIGLEC9

BALB/c-hPD1/hPDL1/hSIGLEC9

T015774

SIGLEC9

B6-hSIGLEC9

T037340

SIGLEC9

B6-hPD1/hPDL1/hSIGLEC9

T058950

SIGLEC8

BALB/c-hSIGLEC8

T058257

SIGLEC7/SIGLEC9

B6-hSIGLEC7/hSIGLEC9

T057695

SIGLEC6

BALB/c-hSIGLEC6

T037094

SIGLEC15

BALB/c-hPD1/hPDL1/hSIGLEC15

T014939

SIGLEC15

B6-hSIGLEC15

T037006

SIGLEC15

B6-hPD1/hPDL1/hSIGLEC15

T054093

SIGLEC10

BALB/c-hSIGLEC10

T056079

SEMA4D

BALB/c-hSEMA4D

T056875

SELPLG

BALB/c-hSELPLG

T055267

RSPO3

BALB/c-hRSPO3

T055266

RSPO1

BALB/c-hRSPO1

T060323

RAGE

B6-hRAGE

T054682

PVRIG

BALB/c-hPVRIG

T058209

PRDM1

B6-hPRDM1 Tg-mPRDM1 KO

T054136

PGFRB

B6-hPGFRB

T059340

PGFRA

B6-hPDGFRA

T055358

PE2R2

BALB/c-hPE2R2

T055357

PE2R1

BALB/c-hPE2R1

T003260

PDL1

BALB/c-hPDL1

T003455

PDL1

B6-hPDL1

T004025

PD1/PDL1

BALB/c-hPD1/hPDL1

T004022

PD1/PDL1

B6-hPD1/hPDL1

T002726

PD1

BALB/c-hPD1

T003095

PD1

B6-hPD1

T055273

OX40/OX40L

BALB/c-hOX40/hOX40L

T064369

OX40/OX40L

B6-hOX40/hOX40L

T050263

OX40

BALB/c-hPD1/hPDL1/hOX40

T003804

OX40

BALB/c-hPD1/hOX40

T004363

OX40

BALB/c-hOX40

T004421

OX40

B6-hPD1/hOX40

T002140

OX40

B6-hOX40

T056424

NTRK1

BALB/c-hNTRK1

T014770

NT5E

BALB/c-hPDL1/hNT5E

T057500

NKp80(CLEC2B)

BALB/c-hNKp80/AICL-Tg

T054080

NKp46

NOD-Scid-hNKp46

T054840

NKp46

BALB/c-hNKp46

T054839

NKp46

B6-hNKp46

T057642

NKp30/NKp44

BALB/c-Tg(hNKp30/hNKp44)

T054081

NKp30

NOD-Scid-hNKp30

T057502

NKG2A/NKG2C/NKG2D/NKG2E/NKG2F/CD94

BALB/c-hNKG2ACDEF -Tg

T054134

NKG2

NOD-Scid-hNKG2ACDEF

T054085

NECTIN-4

NCG-hNECTIN-4

T056430

NECTIN-4

BALB/c-hNECTIN-4

T056431

NECTIN-4

B6-hNECTIN-4

T056082

MUC17

B6-hMUC17

T036853

MSLN

NCG-hMSLN

T036851

MSLN

BALB/c-hMSLN

T058350

MICB005

B6-hMICB005

T064234

MET

B6-hMET

T056328

MERTK

BALB/c-hMERTK

T064509

MARCO

BALB/c-hMARCO

T015882

LRRC32

B6-hLRRC32

T056083

LRRC15

BALB/c-hLRRC15

T059590

LRRC15

B6-hLRRC15

T058104

LILRB1/LILRB2/LILRB3/LILRB4/LILRB5

BALB/c-hLILRB1/hLILRB2/hLILRB3/hLILRB4/hLILRB5

T055265

LGR6

BALB/c-hLGR6

T055264

LGR5

BALB/c-hLGR5

T060158

LAIR1

B6-hPD1/hPDL1/hLAIR1

T055501

LAG3/TIGIT

BALB/c-hPD1/hPDL1/hLAG3/hTIGIT

T054544

LAG3/hFGL1

BALB/c-hLAG3/hFGL1

T037005

LAG3

BALB/c-hPD1/hPDL1/hLAG3

T004622

LAG3

BALB/c-hPD1/hLAG3

T007083

LAG3

BALB/c-hLAG3

T006876

LAG3

B6-hPD1/hPDL1/hLAG3

T004621

LAG3

B6-hPD1/hLAG3

T003597

LAG3

B6-hLAG3

T037679

KLRK1(NKG2D)

B6-hKLRK1(NKG2D)

T054644

KLRB1

NOD-Scid-hKLRB1 Humanized

T054645

KLRB1

BALB/c-hKLRB1

T057243

ITGAL

BALB/c-hITGAL

T055878

IL2RG

BALB/c-hIL2RG

T055877

IL2RB

BALB/c-hIL2RB

T036802

IL2RA

hIL2RA

T055629

IL2RA

BALB/c-hPD1/hPDL1/hIL2RA

T059715

IL2RA

BALB/c-hIL2RA

T053556

IL1B/PD1

BALB/c-hIL1B/hPD1

T053555

IL1B

BALB/c-hIL1B

T053317

IL18R1/IL18RAP

BALB/c-hIL18R1/hIL18RAP

T053316

IL18R1/IL18RAP

B6-hIL18R1/hIL18RAP

T056078

IGF1R

BALB/c-IGF1R

T054201

IDO2

B6-hIDO2

T054200

IDO1

B6-hIDO1

T056427

ICOS

BALB/c-ICOS-KO

T058442

ICOS

BALB/c-hPD1/hPDL1/hICOS

T059642

ICAM1

BALB/c-hICAM1

T059729

HVEM

BALB/c-hHVEM

T054543

HSA

BALB/c-HSA

T057193

HLA-DR4

BALB/c-hHLA-DR4

T055184

HIF1A

BALB/c-hHIF1A

T009813

HER2

NCG-hHER2

T009819

HER2

BALB/c-hHER2-tg

T057039

HER2

BALB/c-hHER2

T055360

GPRC5D

BALB/c-hGPRC5D

T057416

GPR35

B6-hGPR35

T054198

GPC3

BALB/c-hGPC3

T053839

GPA33

NCG-hGPA33

T053837

GPA33

BALB/c-hGPA33

T004061

GITR

BALB/c-hPD1/hGITR

T054492

FLT4(VEGFR3)

B6-hFLT4(VEGFR3)

T054196

FLT3

BALB/c-hFLT3

T056654

FLT3

B6-FLT3-ITD

T055885

FGL2

BALB/c-hFGL2

T055886

FGL2

B6-hFGL2

T060105

FAS

B6-hFAS

T060133

FAP

Humanized FAP

T056001

FAP

BALB/c-hFAP

T060378

FAD4T

NCG-FAD4T

T056498

F3

B6-hF3

T058085

ENPP1

BALB/c-hENPP1

T009811

EGFR

NCG-hEGFR

T009817

EGFR

BALB/c-hEGFR

T064257

EBI3

B6-hEBI3

T059103

DRA01-DRB10901

NCG-hDRA01-hDRB10901

T054646

Dr5(TNFRSF10B)

BALB/c-hDr5(TNFRSF10B)

T055632

DLL4

BALB/c-hDLL4

T055631

DLL4

B6-hDLL4

T057818

DLK1

BALB/c-hDLK1

T056326

DLK1

B6-hDLK1

T056652

DDR1

B6-hDDR1

T055127

CXCR6

BALB/c-hCXCR6

T055271

CXCR4

BALB/c-hCXCR4

T059095

CXCR3

BALB/c-hCXCR3

T056874

CXCR2

BALB/c-hCXCR2

T057029

CTLA4/SIRPa

B6-hCTLA4/hSIRPa

T064418

CTLA4/CD47/SIRPα

BALB/c-hCTLA4/hCD47/hSIRPα

T007058

CTLA4

BALB/c-hPD1/hPDL1/hCTLA4

T003720

CTLA4

BALB/c-hPD1/hCTLA4

T003361

CTLA4

BALB/c-hCTLA4

T003826

CTLA4

B6-hPD1/hCTLA4

T003362

CTLA4

B6-hCTLA4

T054550

CSF2RB

B6-hCSF2RB

T056329

CSF2RA

B6-hCSF2RA

T057788

CSF2/IL3

BALB/c-hCSF2/hIL3

T015766

CSF1R

BALB/c-hPDL1/hCSF1R

T006213

CSF1R

B6-hPD1/hCSF1R

T014759

CSF1R

B6-hCSF1R

T036902

CSF1

B6-hCSF1

T055714

CS1

BALB/c-hCS1

T057241

CRBN

BALB/c-hCRBN

T054279

CLL1

BALB/c-hCLL1

T055368

CLEC7A

BALB/c-hCLEC7A

T054643

CLEC5A

BALB/c-hCLEC5A

T054478

CLEC2D(LLT1)

BALB/c-hCLEC2D(LLT1)

T059586

CLEC1A

B6-hCLEC1A

T055716

CLEC14A

BALB/c-hCLEC14A

T057501

CEACAM6

BALB/c-hCEACAM6

T059591

CEACAM5

BALB/c-hCEACAM5(BAC-Tg)

T058753

CEACAM5

B6-hCEACAM5(BAC-Tg)

T056497

CEACAM1

BALB/c-hCEACAM1

T058628

CD98hc

BALB/c-hPD1/hPDL1/hCD98hc

T060056

CD98hc

B6-hCD98HC

T054647

CD93

BALB/c-hCD93

T059256

CD9

BALB/c-hCD9

T058947

CD79

BALB/c-hCD79a/hCD79b

T054480

CD74

BALB/c-hCD74

T058749

CD73/CD39

BALB/c-hPD1/hPDL1/hCD73/hCD39

T036652

CD73

BALB/c-hPD1/hPDL1/hCD73

T009410

CD73

B6-hPD1/hPDL1/hCD73

T014695

CD73

B6-hCD73

T055129

CD70

BALB/c-hCD70

T059463

CD7

BALB/c-hCD7

T055016

CD69

BALB/c-hCD69

T059096

CD6

BALB/c-hCD6

T059698

CD55

B6-hCD55

T055884

CD52

BALB/c-hCD52

T057924

CD5

BALB/c-hCD5

T056521

CD5

B6-hCD5

T050195

CD47/SIRPα

BALB/c-hPD1/hPDL1/hCD47/hSIRPA

T059127

CD47/SIRPα

BALB/c-hFcgRs-TG/mFcgRs-KO/hCD47/hSIRPA

T037264

CD47/SIRPα

BALB/c-hCD47/hSIRPα

T037007

CD47/SIRPα

B6-hCD47/hSIRPα

T005313

CD47

BALB/c-hPD1/hCD47

T014646

CD47

BALB/c-hCD47

T036820

CD47

B6-hPD1/hPDL1/hCD47

T004666

CD47

B6-hPD1/hCD47

T007666

CD47

B6-hCD47

T064265

CD46

B6-hCD46

T056011

CD44v6

BALB/c-hCD44v6

T056010

CD44

BALB/c-hCD44

T055018

CD40

BALB/c-hPD1/hPDL1/hCD40

T051430

CD40

BALB/c-hCD40

T036974

CD39

BALB/c-hPD1/hPDL1/hCD39

T057786

CD38

BALB/c-hPD1/hPDL1/CD38

T060262

CD38

BALB/c-hCD38

T054000

CD38

B6-hCD38

T059415

CD37

BALB/c-hCD37

T056429

CD34

B6-hCD34

T054139

CD33

BALB/c-hCD33

T054092

CD30

BALB/c-hCD30

T050041

CD3/MSLN

BALB/c-hCD3E/hMSLN

T017537

CD3/KDR

BALB/c-hCD3E/hKDR

T058817

CD3/GPRC5D

BALB/c-hGPRC5D/hCD3EDG

T053838

CD3/GPA33

BALB/c-hCD3E/hGPA33

T057420

CD3/CD73

BALB/c-hCD73/hCD3EDG

T057819

CD3/CD5

BALB/c-hCD3/hCD5

T057544

CD3/CD28

BALB/c-hCD3EDG/hCD28

T055717

CD3/CD28

BALB/c-hCD3E/hCD28

T056765

CD3/CD19

BALB/c-Tg(hCD3EDG)/Gpt-hCD19

T063937

CD3/CD19

BALB/c-hCD3EDG/hCD19

T009031

CD3

BALB/c-Tg(hCD3EDG)

T053483

CD3

BALB/c-hCD3EDG

T001550

CD3

BALB/c-hCD3E

T054368

CD3

B6-mCD3EDG-KO

T064461

CD3

B6-hCD3EDG [BAC]

T064289

CD3

B6-CD3EDG

T014895

CD28

hCD28

T064376

CD28

BALB/c-hCD28

T004279

CD28

B6-hPD1/hCD28

T057467

CD276(B7-H3)

BALB/c-hPDL1/hCD276

T056502

CD276(B7-H3)

BALB/c-hCD276

T057466

CD276(B7-H3)

B6-hPDL1/hCD276

T056501

CD276(B7-H3)

B6-hCD276

T059765

CD27/CD70

BALB/C-hCD27/hCD70

T053821

CD27

BALB/c-hPD1/hPDL1/hCD27

T037422

CD27

BALB/c-hPD1/hCD27

T055128

CD27

BALB/c-hCD27

T006778

CD27

B6-hPD1/hCD27

T059695

CD24/Siglec10

BALB/c-hCD24/hSIGLEC10

T054140

CD24

BALB/c-hCD24

T064282

CD24

B6-hCD24-CKO

T064459

CD24

B6-hCD24

T054581

CD228(MELTF)

NCG-hCD228(MELTF)

T058940

CD22

BALB/c-hCD3EDG/hCD22

T054197

CD22

BALB/c-hCD22

T057498

CD20

BALB/c-hCD20-tg

T054538

CD138

NCG-hCD138

T054537

CD138

BALB/c-hCD138

T064372

CD137/CD40

BALB/c-hCD137/hCD40

T007056

CD137

BALB/c-hPD1/hPDL1/hCD137

T004005

CD137

BALB/c-hPD1/hCD137

T003359

CD137

BALB/c-hCD137

T057201

CD137

B6-hPD1/hPDL1/hCD137

T004082

CD137

B6-hPD1/hCD137

T003360

CD137

B6-hCD137

T054365

CD125

B6-hIL5RA(CD125)

T060366

CD112

BALB/c-hCD112

T059368

CCR7

BALB/c-hCCR7

T059551

CCR5

BALB/c-hCCR5

T056327

CCR2

BALB/c-hCCR2

T055882

CA9

B6-hCA9

T056524

BTN3A1

BALB/c-hBTN3A1

T056523

BTN3A1

B6-hBTN3A1

T059683

BTLA

BALB/c-hPD1/PDL1/BTLA

T059683

BTLA

BALB/c-hPD1/PDL1/BTLA

T006779

BTLA

BALB/c-hBTLA

T006779

BTLA

BALB/c-hBTLA

T004138

BTLA

BALB/c-hPD1/hBTLA

T059045

BCMA

BALB/c-hCD3EDG/hBCMA

T054078

BCMA

BALB/c-hBCMA

T055999

ANGPT2

BALB/c-hANGPT2

T055883

ANG

B6-hANG

T054124

ALK

NCG-hALK

T060135

ALCAM

BALB/c-hALCAM

T056761

ADAM17

BALB/c-hADAM17

T055126

A2aR

BALB/c-hA2aR

T009882

VTCN1

BALB/c-hVTCN1

T009880

VTCN1

B6-hVTCN1

T059647

VSIG4

BALB/c-hVSIG4

T014757

VISTA

BALB/c-hVISTA

T054369

VEGFR1(FLT1)

B6-hVEGFR1(FLT1)

T054677

VEGFD

B6-hVEGFD

T055634

VEGFC

BALB/c-hVEGFC

T055633

VEGFB

BALB/c-hVEGFB

T054634

VEGFB

B6-hVEGFB

T059100

VEGFA/VEGFR2

BALB/c-hVEGFA/hVEGFR2

T017804

VEGFA

NCG-hVEGFA

T017803

VEGFA

BALB/c-hVEGFA

T056432

TROP2

BALB/c-hTROP2

T058949

TREM2

BALB/c-hTREM2

T056008

TREM2

B6-hTREM2

T064513

TREM1

BALB/c-hTREM1

T055353

TPOR

BALB/c-hTPOR

T058456

TNFR2

BALB/c-hTNFR2

T037079

TNFR2

BALB/c-hPD1/hTNFR2

T055369

TNFR2

BALB/c-hPD1/hPDL1/hTNFR2

T054585

TLR9

BALB/c-hTLR9

T054584

TLR9

B6-hTLR9

T054553

TLR7

BALB/c-hTLR7

T054552

TLR7

B6-hTLR7

T056526

TLR2

BALB/c-hTLR2

T003894

TIM3

BALB/c-hTIM3

T004795

TIM3

BALB/c-hPD1/hTIM3

T007059

TIM3

BALB/c-hPD1/hPDL1/hTIM3

T009737

TIM3

B6-hPD1/hTIM3

T058266

TIGIT/PVRIG

BALB/c-hTIGIT/hPVRIG

T059704

TIGIT/PVRIG

BALB/c-hPD1/hPDL1/hTIGIT/hPVRIG

T056729

TIGIT/OX40

BALB/c-hTIGIT/hOX40

T055241

TIGIT/CTLA4

BALB/c-hTIGIT/hCTLA4

T054842

TIGIT/CD96

BALB/c-hPD1/hPDL1/hTIGIT/hCD96

T054841

TIGIT/CD226

BALB/c-hPD1/hPDL1/hTIGIT/hCD226

T059259

TIGIT/CD155

BALB/c-hTIGIT/hCD155-full

T059258

TIGIT/CD155

BALB/c-hTIGIT/hCD155

T003365

TIGIT

BALB/c-hTIGIT

T004023

TIGIT

BALB/c-hPD1/hTIGIT

T051156

TIGIT

BALB/c-hPD1/hPDL1/hTIGIT/hCTLA4

T037004

TIGIT

BALB/c-hPD1/hPDL1/hTIGIT

T058886

TIGIT

BALB/c-hFcgRs-Tg/hTIGIT/mFcgRs-KO

T003366

TIGIT

B6-hTIGIT

T004024

TIGIT

B6-hPD1/hTIGIT

T006873

TIGIT

B6-hPD1/hPDL1/hTIGIT

T064267

TGFR2

B6-hTGFR2

T064266

TGFR1

B6-hTGFR1

T054838

TGFB2

BALB/c-hTGFB2

T054837

TGFB1

BALB/c-hTGFB1

T055118

TFRC(TfR1)

BALB/c-hTFRC(hTfR1)

T054281

TDO2

B6-hTDO2

T054362

TACSTD2(TROP2)

NCG-hTACSTD2(TROP2)

T056080

SSTR2

BALB/c-hSSTR2

T005314

SIRPα

BALB/c-hPD1/hSIRPα

T050194

SIRPα

BALB/c-hPD1/hPDL1/hSIRPα

T004615

SIRPα

B6-hSIRPα

T006929

SIRPα

B6-hPD1/hSIRPα

T036819

SIRPA

B6-hPD1/hPDL1/hSIRPA

T037008

SIGLEC9

BALB/c-hSIGLEC9

T037010

SIGLEC9

BALB/c-hPD1/hPDL1/hSIGLEC9

T015774

SIGLEC9

B6-hSIGLEC9

T037340

SIGLEC9

B6-hPD1/hPDL1/hSIGLEC9

T058950

SIGLEC8

BALB/c-hSIGLEC8

T058257

SIGLEC7/SIGLEC9

B6-hSIGLEC7/hSIGLEC9

T057695

SIGLEC6

BALB/c-hSIGLEC6

T037094

SIGLEC15

BALB/c-hPD1/hPDL1/hSIGLEC15

T014939

SIGLEC15

B6-hSIGLEC15

T037006

SIGLEC15

B6-hPD1/hPDL1/hSIGLEC15

T054093

SIGLEC10

BALB/c-hSIGLEC10

T056079

SEMA4D

BALB/c-hSEMA4D

T056875

SELPLG

BALB/c-hSELPLG

T055267

RSPO3

BALB/c-hRSPO3

T055266

RSPO1

BALB/c-hRSPO1

T060323

RAGE

B6-hRAGE

T054682

PVRIG

BALB/c-hPVRIG

T058209

PRDM1

B6-hPRDM1 Tg-mPRDM1 KO

T054136

PGFRB

B6-hPGFRB

T059340

PGFRA

B6-hPDGFRA

T055358

PE2R2

BALB/c-hPE2R2

T055357

PE2R1

BALB/c-hPE2R1

T003260

PDL1

BALB/c-hPDL1

T003455

PDL1

B6-hPDL1

T004025

PD1/PDL1

BALB/c-hPD1/hPDL1

T004022

PD1/PDL1

B6-hPD1/hPDL1

T002726

PD1

BALB/c-hPD1

T003095

PD1

B6-hPD1

T055273

OX40/OX40L

BALB/c-hOX40/hOX40L

T064369

OX40/OX40L

B6-hOX40/hOX40L

T050263

OX40

BALB/c-hPD1/hPDL1/hOX40

T003804

OX40

BALB/c-hPD1/hOX40

T004363

OX40

BALB/c-hOX40

T004421

OX40

B6-hPD1/hOX40

T002140

OX40

B6-hOX40

T056424

NTRK1

BALB/c-hNTRK1

T014770

NT5E

BALB/c-hPDL1/hNT5E

T057500

NKp80(CLEC2B)

BALB/c-hNKp80/AICL-Tg

T054080

NKp46

NOD-Scid-hNKp46

T054840

NKp46

BALB/c-hNKp46

T054839

NKp46

B6-hNKp46

T057642

NKp30/NKp44

BALB/c-Tg(hNKp30/hNKp44)

T054081

NKp30

NOD-Scid-hNKp30

T057502

NKG2A/NKG2C/NKG2D/NKG2E/NKG2F/CD94

BALB/c-hNKG2ACDEF -Tg

T054134

NKG2

NOD-Scid-hNKG2ACDEF

T054085

NECTIN-4

NCG-hNECTIN-4

T056430

NECTIN-4

BALB/c-hNECTIN-4

T056431

NECTIN-4

B6-hNECTIN-4

T056082

MUC17

B6-hMUC17

T036853

MSLN

NCG-hMSLN

T036851

MSLN

BALB/c-hMSLN

T058350

MICB005

B6-hMICB005

T064234

MET

B6-hMET

T056328

MERTK

BALB/c-hMERTK

T064509

MARCO

BALB/c-hMARCO

T015882

LRRC32

B6-hLRRC32

T056083

LRRC15

BALB/c-hLRRC15

T059590

LRRC15

B6-hLRRC15

T058104

LILRB1/LILRB2/LILRB3/LILRB4/LILRB5

BALB/c-hLILRB1/hLILRB2/hLILRB3/hLILRB4/hLILRB5

T055265

LGR6

BALB/c-hLGR6

T055264

LGR5

BALB/c-hLGR5

T060158

LAIR1

B6-hPD1/hPDL1/hLAIR1

T055501

LAG3/TIGIT

BALB/c-hPD1/hPDL1/hLAG3/hTIGIT

T054544

LAG3/hFGL1

BALB/c-hLAG3/hFGL1

T037005

LAG3

BALB/c-hPD1/hPDL1/hLAG3

T004622

LAG3

BALB/c-hPD1/hLAG3

T007083

LAG3

BALB/c-hLAG3

T006876

LAG3

B6-hPD1/hPDL1/hLAG3

T004621

LAG3

B6-hPD1/hLAG3

T003597

LAG3

B6-hLAG3

T037679

KLRK1(NKG2D)

B6-hKLRK1(NKG2D)

T054644

KLRB1

NOD-Scid-hKLRB1 Humanized

T054645

KLRB1

BALB/c-hKLRB1

T057243

ITGAL

BALB/c-hITGAL

T055878

IL2RG

BALB/c-hIL2RG

T055877

IL2RB

BALB/c-hIL2RB

T036802

IL2RA

hIL2RA

T055629

IL2RA

BALB/c-hPD1/hPDL1/hIL2RA

T059715

IL2RA

BALB/c-hIL2RA

T053556

IL1B/PD1

BALB/c-hIL1B/hPD1

T053555

IL1B

BALB/c-hIL1B

T053317

IL18R1/IL18RAP

BALB/c-hIL18R1/hIL18RAP

T053316

IL18R1/IL18RAP

B6-hIL18R1/hIL18RAP

T056078

IGF1R

BALB/c-IGF1R

T054201

IDO2

B6-hIDO2

T054200

IDO1

B6-hIDO1

T056427

ICOS

BALB/c-ICOS-KO

T058442

ICOS

BALB/c-hPD1/hPDL1/hICOS

T059642

ICAM1

BALB/c-hICAM1

T059729

HVEM

BALB/c-hHVEM

T054543

HSA

BALB/c-HSA

T057193

HLA-DR4

BALB/c-hHLA-DR4

T055184

HIF1A

BALB/c-hHIF1A

T009813

HER2

NCG-hHER2

T009819

HER2

BALB/c-hHER2-tg

T057039

HER2

BALB/c-hHER2

T055360

GPRC5D

BALB/c-hGPRC5D

T057416

GPR35

B6-hGPR35

T054198

GPC3

BALB/c-hGPC3

T053839

GPA33

NCG-hGPA33

T053837

GPA33

BALB/c-hGPA33

T004061

GITR

BALB/c-hPD1/hGITR

T054492

FLT4(VEGFR3)

B6-hFLT4(VEGFR3)

T054196

FLT3

BALB/c-hFLT3

T056654

FLT3

B6-FLT3-ITD

T055885

FGL2

BALB/c-hFGL2

T055886

FGL2

B6-hFGL2

T060105

FAS

B6-hFAS

T060133

FAP

Humanized FAP

T056001

FAP

BALB/c-hFAP

T060378

FAD4T

NCG-FAD4T

T056498

F3

B6-hF3

T058085

ENPP1

BALB/c-hENPP1

T009811

EGFR

NCG-hEGFR

T009817

EGFR

BALB/c-hEGFR

T064257

EBI3

B6-hEBI3

T059103

DRA01-DRB10901

NCG-hDRA01-hDRB10901

T054646

Dr5(TNFRSF10B)

BALB/c-hDr5(TNFRSF10B)

T055632

DLL4

BALB/c-hDLL4

T055631

DLL4

B6-hDLL4

T057818

DLK1

BALB/c-hDLK1

T056326

DLK1

B6-hDLK1

T056652

DDR1

B6-hDDR1

T055127

CXCR6

BALB/c-hCXCR6

T055271

CXCR4

BALB/c-hCXCR4

T059095

CXCR3

BALB/c-hCXCR3

T056874

CXCR2

BALB/c-hCXCR2

T057029

CTLA4/SIRPa

B6-hCTLA4/hSIRPa

T064418

CTLA4/CD47/SIRPα

BALB/c-hCTLA4/hCD47/hSIRPα

T007058

CTLA4

BALB/c-hPD1/hPDL1/hCTLA4

T003720

CTLA4

BALB/c-hPD1/hCTLA4

T003361

CTLA4

BALB/c-hCTLA4

T003826

CTLA4

B6-hPD1/hCTLA4

T003362

CTLA4

B6-hCTLA4

T054550

CSF2RB

B6-hCSF2RB

T056329

CSF2RA

B6-hCSF2RA

T057788

CSF2/IL3

BALB/c-hCSF2/hIL3

T015766

CSF1R

BALB/c-hPDL1/hCSF1R

T006213

CSF1R

B6-hPD1/hCSF1R

T014759

CSF1R

B6-hCSF1R

T036902

CSF1

B6-hCSF1