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PDX模型

PDX模型（Patient-Derived tumor Xenograft model）为人源肿瘤异种移植瘤模型，主要通过将病人的新鲜肿瘤组织移植到免疫缺陷小鼠(如NCG)上构建而成。该模型能较完整地保持患者肿瘤原有的生物学特征、病理分型、分子标志物表达、基因突变类型等，保留了肿瘤的异质性、多样性和肿瘤微环境特征。集萃药康可提供多癌种PDX模型和基于PDX模型的药物筛选和药理药效分析服务。

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胰腺癌PDX（Patient-Derived Xenograft）是一种用于研究和治疗胰腺癌的模型。它是通过将从患者体内获取的胰腺癌组织或细胞移植到小鼠等实验动物中形成的模型。胰腺癌PDX模型是一种重要的实验工具，可用于研究胰腺癌的发生机制、药物研发和个体化治疗策略的评估。

  PDX ID

 Histological type    

Grade

Stage

WES      

RNA-seq     

PC00125

Adenocarcinoma

Low to medium differentiation

N/A

N/A

N/A

PC00148

Adenocarcinoma

N/A

N/A

Y

Y

PC00169

Ductal adenocarcinoma

Low to medium differentiation

N/A

N/A

Y

PC00182

Ductal adenocarcinoma

Low to medium differentiation

N/A

N/A

Y

PC00183

Ductal adenocarcinoma

Low to medium differentiation

N/A

N/A

N/A

PC00184

Ductal adenocarcinoma

Poorly differentiated

N/A

N/A

N/A

PC00187

Ductal adenocarcinoma

Moderate-severe differentiation

N/A

N/A

N/A

PC00188

Ductal adenocarcinoma

Low to medium differentiation

N/A

N/A

N/A

PC00196

Ductal adenocarcinoma

Low to medium differentiation

N/A

Y

Y

PC00204

Adenocarcinoma

Moderately differentiated

N/A

N/A

N/A

PC00205

Ductal adenocarcinoma

Moderately differentiated

N/A

N/A

Y

PC00206-1

Ductal adenocarcinoma

Moderately differentiated

N/A

Y

N/A

PC00210

Ductal adenocarcinoma

Moderately differentiated

N/A

N/A

Y

PC00211

Ductal adenocarcinoma

Low to medium differentiation

N/A

N/A

Y

PC00212

Ductal adenocarcinoma

Moderate-severe differentiation

N/A

N/A

Y

PC00225

Ductal adenocarcinoma

Moderately differentiated

N/A

N/A

Y

PC00226

Ductal adenocarcinoma

Low to medium differentiation

N/A

N/A

Y

PC00231

N/A

N/A

N/A

N/A

Y

PC00236

N/A

N/A

N/A

N/A

Y

PC00237

N/A

N/A

N/A

N/A

Y

PC00250

Ductal adenocarcinoma

Low to medium differentiation

N/A

N/A

Y

PC00253

N/A

N/A

N/A

N/A

Y

PC00254

N/A

N/A

N/A

N/A

N/A

PC00258

N/A

N/A

N/A

N/A

N/A

PC00263

N/A

N/A

N/A

N/A

Y

PC00264

Undifferentiated carcinoma of the pancreas

N/A

N/A

N/A

Y

PC00266

N/A

N/A

N/A

N/A

Y

PC00279

N/A

N/A

N/A

N/A

N/A

PC00283

N/A

N/A

N/A

N/A

Y

PC00285

N/A

N/A

N/A

Y

Y

PC00287

N/A

N/A

N/A

N/A

Y

PC00290

N/A

N/A

N/A

Y

Y

PC00291

N/A

N/A

N/A

N/A

Y

PC00292

N/A

N/A

N/A

N/A

Y

PC00296

N/A

N/A

N/A

N/A

Y

PC00297

N/A

N/A

N/A

N/A

Y

PC00299

Ductal adenocarcinoma

Moderately differentiated

N/A

N/A

Y

PC00313

Malignant gastrointestinal stromal tumor

N/A

N/A

N/A

Y

PC00315

N/A

N/A

N/A

N/A

Y

PC00329

N/A

N/A

N/A

N/A

Y

PC00330

Adenocarcinoma

Low to medium differentiation

N/A

N/A

Y

PC00331

Ductal adenocarcinoma

Low to medium differentiation

N/A

N/A

N/A

PC00341

N/A

N/A

N/A

N/A

Y

PC00376

N/A

N/A

N/A

N/A

Y

PC00377

N/A

N/A

N/A

N/A

Y

PC00399

N/A

N/A

N/A

N/A

N/A

PC00410

Ductal adenocarcinoma

Low to medium differentiation

N/A

N/A

Y

PC00414

N/A

N/A

N/A

N/A

Y

PC00425

Ductal adenocarcinoma

Moderate-severe differentiation

N/A

Y

Y

PC00426

Ductal adenocarcinoma

Low to medium differentiation

N/A

N/A

N/A

PC00440

N/A

N/A

N/A

N/A

Y

PC00454

N/A

N/A

N/A

N/A

Y

PC00455

N/A

N/A

N/A

N/A

Y

PC00477

N/A

N/A

N/A

N/A

N/A

PC00481

N/A

N/A

N/A

N/A

Y

PC00484

N/A

N/A

N/A

Y

Y

PC00505

N/A

N/A

N/A

N/A

Y

PC00521

N/A

N/A

N/A

N/A

N/A

PC00526

N/A

N/A

N/A

Y

Y

PC00539

Ductal adenocarcinoma

Moderately differentiated

N/A

N/A

N/A

PC00541

Ductal adenocarcinoma

Low to medium differentiation

N/A

N/A

Y

PC00564

N/A

N/A

N/A

N/A

Y

PC00572

N/A

N/A

N/A

N/A

Y

PC00573

N/A

N/A

N/A

N/A

N/A

PC00601

Adenocarcinoma

N/A

N/A

N/A

N/A

PC00611

Low-moderate differentiate adenocarcinoma

N/A

N/A

N/A

N/A

PC00625

N/A

N/A

T2N0M0

N/A

N/A

PC00627

N/A

N/A

    ⅡB(T3N1M0)    

N/A

N/A

PC00633

Adenocarcinoma

N/A

N/A

N/A

N/A

PC00696

  Moderately differentiated adenocarcinoma

N/A

N/A

N/A

N/A



品系编号 靶点 品系简称 应用领域

T053302

APP/PSEN1

FAD4T

阿尔茨海默病